EPA Issues Toxicological Review of Acrylamide

The U.S. Environmental Protection Agency (EPA) has issued a “Toxicological Review of Acrylamide” in support of information on its Integrated Risk Information System. The chemical, which is formed during the high-temperature heating of starchy foods, is also used in a number of industrial processes and in adhesives and grouts. According to the agency, many laboratory animal studies have indicated degenerative peripheral nerve changes from repeated oral exposures as well as impaired male reproductive performance and genetic damage. The review also notes that the agency characterizes the chemical as “likely to be carcinogenic to humans” on the basis of dermal and drinking-water exposure in rats. According to the review, occupational exposure studies “are sufficient to firmly establish neurological impairment as a potential health hazard from inhalation and dermal exposure.”