The European Food Safety Authority (EFSA) has issued a statement rejecting an Italian study claiming a link between the use of the sweetener sucralose and cancer in mice. The EFSA Journal’s review of a 10-year study conducted by the Ramazzini Institute criticized the study’s design and methodology, concluding that available data does not support the institute’s claim that sucralose may cause lymphoma or leukemia in mice. Among other criticisms, the panel said the design introduced too many variable factors that could make the data difficult to interpret, and there was no demonstrated dose-response relationship between exposure to sucralose and incidence of cancer. EFSA also pointed to the study’s failure to establish a cause-effect relationship in epidemiological studies and said there was no reliable evidence of in vivo or in vitro genotoxicity. Issue 634
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