Animal Study Mimics Dietary BPA Exposure in Humans

University of Missouri scientists have reportedly published the first study to examine “serum BPA [bisphenol A] concentrations in an animal model exposed to this chemical via the diet,” as opposed to oral bolus exposure. Paizlee Sieli, et al., “Comparison of Serum Bisphenol A Concentrations in Mice Exposed to Bisphenol A through the Diet Versus Oral Bolus Exposure,” Environmental Health Perspectives, June 6, 2011. After comparing BPA serum concentrations in adult female mice after oral bolus administration or ad libitum feeding, researchers concluded that bolus administration “underestimates bioavailable serum BPA concentrations in animals and therefore, presumably humans than would result from dietary exposure.” According to the study, these results suggest that “exposure via diet is a more natural continuous exposure route than oral bolus exposure, and thus, a better predictor of BPA concentrations in chronically exposed animals and humans.”