The U.S. Environmental Protection Agency (EPA) has published preliminary materials for the Integrated Risk Information System (IRIS) toxicological review of diisononyl phthalate (DINP), a plasticizer used in food-contact materials.Slated for discussion at the IRIS Bimonthly Public Science Meeting to be held October 29-30, 2014, in Arlington, Virginia, the preliminary materials include (i) “a planning and scoping summary,” (ii) “information on the approaches used to identify pertinent literature,” (iii) “results of the literature search,” (iv) “approaches for selection of studies for hazard identification,” (v) “presentation of critical studies in evidence tables and exposure-response arrays,” and (vi) “mechanistic information for DINP.”

In addition to feedback on these general topics, EPA has specifically requested public comment and discussion on “DINP-induced liver effects, including spongiosis hepatis”; “the evidence for DINP-induced male reproductive toxicity; “the relevance of the xenograft and ex-vivo tissue studies”; the human relevance of animal studies associating mononuclear cell leukemia with DINP exposure; and the “transparency and utility of mechanistic data.” The agency is also seeking “any additional studies published or nearing publication that may provide data for the evaluation of human health hazard or dose-response relationships.”


Issue 537

About The Author


For decades, manufacturers, distributors and retailers at every link in the food chain have come to Shook, Hardy & Bacon to partner with a legal team that understands the issues they face in today's evolving food production industry. Shook attorneys work with some of the world's largest food, beverage and agribusiness companies to establish preventative measures, conduct internal audits, develop public relations strategies, and advance tort reform initiatives.

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